Oxygen Headspace Analysis for Air Headspace to Develop and Validate Container Closure Integrity Methods

Oxygen Headspace Analysis for Air Headspace to Develop and Validate Container Closure Integrity Methods

Abstract

Container closure integrity testing (CCIT) by laser-based headspace oxygen can be performed for samples with an air headspace for the detection of both small (≤20 micron) and large (0.5-2 mm) defects, evaluating the container closure integrity (CCI) of a sample at any point in the product-package life cycle. This article will discuss developing and validating a CCI method using oxygen headspace analysis for air headspace samples, including considerations for different container sizes and fill volumes.